Description

Impute VCF/BCF files, but also CRAM and BAM files with Glimpse2

Input

name
description
pattern

ch_input

Target dataset in CRAM, BAM or VCF/BCF format.
Index file of the input file.
File containing the list of files to be imputed and their sample names (for CRAM/BAM input).
File with sample names and ploidy information.
Structure: [ meta, file, index, bamlist, ploidy ]

ch_ref

Reference panel of haplotypes in VCF/BCF format.
Index file of the Reference panel file.
Target region, usually a full chromosome (e.g. chr20:1000000-2000000 or chr20).
The file could possibly be without GT field (for efficiency reasons a file containing only the positions is recommended).
Structure: [ meta, vcf, csi, region ]

ch_chunks

Channel containing the chunking regions for each chromosome.
Structure: [ meta, region with buffer, region without buffer ]

ch_map

Genetic map file for each chromosome.
Structure: [ meta, gmap ]

ch_fasta

Reference genome in fasta format.
Reference genome index in fai format
Structure: [ meta, fasta, fai ]

chunk

Whether to perform chunking of the input data before imputation.

chunk_model

Chunking model to use.
Options: “sequential”, “recursive”

splitreference

Whether to split the reference panel and convert it to binary files before imputation.

Output

name
description
pattern

ch_chunks

Channel containing the chunking regions for each chromosome.
Structure: [ meta, region with buffer, region without buffer ]

ch_vcf_index

Output VCF/BCF file for the merged regions.
Index file of the output VCF/BCF file.
Structure: [ val(meta), variants, index ]

versions

File containing software versions

versions.yml