nf-core/rnadnavar v1.0.0

The first release of nf-core/rnadnavar is (finally!) here 🚀.

v1.0.0 delivers a full workflow for somatic variant discovery and refinement from DNA and RNA data, covering variant calling, consensus building, filtering, annotation, and RNA-aware rescue and optional realignment. We finallytransition from active development into a stable version of the pipeline.

Highlights

• End-to-end somatic variant workflow from raw or intermediate inputs.
• Support for flexible restart points, including BAM/CRAM, VCF, and MAF-based entry into downstream stages.
• Integrated consensus generation across callers.
• RNA-specific filtering and optional realignment workflow.
• Up-to-date nf-core modules and template components.
• Compatibility with modern Nextflow and stricter syntax rules.
• Comprehensive nf-test coverage, including restart-path testing and local workflow logic.

What’s next

With the first release now out, development will of course continue. The main priority for upcoming work is support for a much-requested tumour-only mode. Other suggestions, feature requests, and collaborations are always very welcome.